Reactions of amines
Reactions of amines
Formula
RNH₂ + RCOCl → RCONHR + HCl
Real World
Paracetamol (acetaminophen) is manufactured by GlaxoSmithKline through acylation of 4-aminophenol with ethanoic anhydride — a direct application of amine nucleophilic attack on an acyl group.
Exam Focus
When drawing mechanisms, show the lone pair on nitrogen attacking the δ+ carbon — label it as nucleophilic addition-elimination.
How well did you know this?