Amides
Amides
Formula
RCOCl + R′NH₂ → RCONHR′ + HCl
Real World
Paracetamol (acetaminophen), sold globally by GSK, contains an amide bond — its low reactivity due to nitrogen lone-pair delocalisation is why the drug is stable enough to sit on pharmacy shelves for years.
Exam Focus
Explain amide stability by referencing lone-pair delocalisation into the C=O, not just 'resonance' — use a diagram if possible.
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