Friedel-Crafts acylation
Friedel-Crafts acylation
Formula
C₆H₆ + RCOCl →[AlCl₃] C₆H₅COR + HCl
Real World
Pharmaceutical company Bayer uses Friedel-Crafts acylation to build the ketone framework in ibuprofen synthesis, preferring it over alkylation because it avoids unwanted polysubstitution.
Exam Focus
Explain why acylation is preferred over alkylation — the C=O group deactivates the ring, preventing further substitution.
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