Aerobic: pyruvate enters the mitochondrial matrix by active transport
After glycolysis, pyruvate moves into the mitochondria to continue aerobic respiration. The cell uses energy to actively pump pyruvate across the mitochondrial membranes.
Real World
Cyanide poisoning — as in the 1982 Chicago Tylenol murders — blocks the electron transfer chain inside mitochondria, making pyruvate's journey into the matrix ultimately futile.
Exam Focus
State 'active transport' specifically — saying pyruvate 'diffuses' or 'moves' into the matrix will not earn the mark.
Evaluation Scaffold
A four-step framework for high-quality evaluation. Use this for 'assess', 'evaluate', and 'to what extent' questions.
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